MMRN1 Carrier protein for platelet (but not plasma) factor V/Va. Plays a role in the storage and stabilization of factor V in platelets. Upon release following platelet activation, may limit platelet and plasma factor Va-dependent thrombin generation. Ligand for integrin alpha-IIb/beta-3 and integrin alpha-V/beta-3 on activated platelets, and may function as an extracellular matrix or adhesive protein. Synthesized by endothelial cells and megakaryocytes. Stored in platelet alpha granules and endothelial cell Weibel-Palade bodies, following activation of these cells, it is released and attached to megakaryocytes, platelets, endothelium and subendothelium of blood vessels. Not found in plasma. Found in vascular tissues such as placenta, lung, and liver. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Secreted; Secreted, signal peptide
Chromosomal Location of Human Ortholog: 4q22.1
Cellular Component:  extracellular region; platelet alpha granule lumen
Molecular Function:  calcium ion binding; extracellular matrix structural constituent; protein binding
Biological Process:  blood coagulation; cell adhesion; platelet degranulation
Reference #:  Q13201 (UniProtKB)
Alt. Names/Synonyms: 155 kDa platelet multimerin; ECM; Elastin microfibril interface located protein 4; Elastin microfibril interfacer 4; EMILIN-4; EMILIN4; Endothelial cell multimerin; glycoprotein Ia*; GPIA*; MMRN; MMRN1; multimerin 1; Multimerin-1; p-155; p155; Platelet glycoprotein Ia*
Gene Symbols: MMRN1
Molecular weight: 138,110 Da
Basal Isoelectric point: 8.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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