QIK Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily
Chromosomal Location of Human Ortholog: 8q23
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; magnesium ion binding; protein serine/threonine kinase activity
Biological Process:  insulin receptor signaling pathway; intracellular signal transduction; protein autophosphorylation; protein phosphorylation; regulation of insulin receptor signaling pathway
Reference #:  Q3LRT3 (UniProtKB)
Alt. Names/Synonyms: RGD1559698; Salt-inducible kinase 2; Sik2; SNF1-like kinase 2; Snf1lk2
Gene Symbols: Sik2
Molecular weight: 103,095 Da
Basal Isoelectric point: 6.23  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene