HTRA1 Serine protease with a variety of targets, including extracellular matrix proteins such as fibronectin. HTRA1-generated fibronectin fragments further induce synovial cells to up-regulate MMP1 and MMP3 production. May also degrade proteoglycans, such as aggrecan, decorin and fibromodulin. Through cleavage of proteoglycans, may release soluble FGF-glycosaminoglycan complexes that promote the range and intensity of FGF signals in the extracellular space. Regulates the availability of insulin-like growth factors (IGFs) by cleaving IGF-binding proteins. Inhibits signaling mediated by TGF-beta family members. This activity requires the integrity of the catalytic site, although it is unclear whether TGF-beta proteins are themselves degraded. By acting on TGF-beta signaling, may regulate many physiological processes, including retinal angiogenesis and neuronal survival and maturation during development. Intracellularly, degrades TSC2, leading to the activation of TSC2 downstream targets. Belongs to the peptidase S1C family. Widely expressed, with strongest expression in placenta (at protein level). Secreted by synovial fibroblasts. Up-regulated in osteoarthritis and rheumatoid arthritis synovial fluids and cartilage as compared with non-arthritic (at protein level). Note: This description may include information from UniProtKB.
Protein type: EC 3.4.21.-; Protease; Secreted; Secreted, signal peptide
Chromosomal Location of human Ortholog: 10q26.13
Cellular Component:  cytosol; extracellular region; extracellular space; plasma membrane
Molecular Function:  identical protein binding; insulin-like growth factor binding; protein binding; serine-type endopeptidase activity; serine-type peptidase activity
Biological Process:  chorionic trophoblast cell differentiation; dentinogenesis; extracellular matrix disassembly; negative regulation of BMP signaling pathway; negative regulation of defense response to virus; negative regulation of transforming growth factor beta receptor signaling pathway; placenta development; positive regulation of epithelial cell proliferation; proteolysis
Disease: Cerebral Arteriopathy, Autosomal Dominant, With Subcortical Infarcts And Leukoencephalopathy, Type 2; Cerebral Autosomal Recessive Arteriopathy With Subcortical Infarcts And Leukoencephalopathy; Macular Degeneration, Age-related, 7
Reference #:  Q92743 (UniProtKB)
Alt. Names/Synonyms: ARMD7; CADASIL2; CARASIL; High-temperature requirement A serine peptidase 1; HTRA; HtrA serine peptidase 1; HTRA1; IGFBP5-protease; L56; ORF480; protease, serine, 11 (IGF binding); PRSS11; Serine protease 11; Serine protease HTRA1
Gene Symbols: HTRA1
Molecular weight: 51,287 Da
Basal Isoelectric point: 8.09  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene