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ICK
Required for ciliogenesis. Phosphorylates KIF3A. Involved in the control of ciliary length. Regulates the ciliary localization of SHH pathway components as well as the localization of IFT components at ciliary tips. May play a key role in the development of multiple organ systems and particularly in cardiac development. Regulates intraflagellar transport (IFT) speed and negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner and this regulation requires its kinase activity. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in heart, brain, placenta, pancreas, thymus, prostate, testis, ovary, small intestine and colon, with highest levels in placenta and testis. Not detected in spleen. Also expressed in many cancer cell lines. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CMGC group; EC 2.7.11.22; Kinase, protein; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RCK family |
| Chromosomal Location of human Ortholog: 6p12.1 |
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Cellular Component:
ciliary basal body; ciliary base; ciliary tip; cilium; cytosol; fibrillar center; nucleus
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
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Biological Process:
cilium assembly; intracellular signal transduction; intraciliary anterograde transport; intraciliary retrograde transport; intraciliary transport; multicellular organism development; protein phosphorylation; signal transduction
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Disease: Endocrine-cerebroosteodysplasia; Epilepsy, Juvenile Myoclonic, Susceptibility To, 10
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Reference #:
Q9UPZ9
(UniProtKB)
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Alt. Names/Synonyms: Ciliogenesis associated kinase 1; CILK1; ECO; EJM10; hICK; iciliogenesis associated kinase 1; ICK; intestinal cell (MAK-like) kinase; Intestinal cell kinase; KIAA0936; Laryngeal cancer kinase 2; LCK2; MAK-related kinase; MGC46090; MRK; serine/threonine protein kinase; Serine/threonine-protein kinase ICK
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Gene Symbols: CILK1
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Molecular weight:
71,427 Da
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Basal Isoelectric point:
9.79
Predict pI for various phosphorylation states
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