ERK7 In vitro, phosphorylates MBP. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. 3 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: CMGC group; EC 2.7.11.24; Erk7 subfamily; Kinase, protein; MAPK family; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: -
Cellular Component:  autophagosome; bicellular tight junction; cell-cell junction; centriole; ciliary basal body; cytoplasm; cytoplasmic vesicle; extracellular region; Golgi apparatus; meiotic spindle; nucleus
Molecular Function:  ATP binding; chromatin binding; kinase activity; MAP kinase activity; protein binding; protein kinase activity; SH3 domain binding
Biological Process:  cellular response to DNA damage stimulus; dopamine uptake; endoplasmic reticulum organization; MAPK cascade; negative regulation of cell migration; positive regulation of cell proliferation; positive regulation of metaphase/anaphase transition of meiosis I; positive regulation of spindle assembly; positive regulation of telomerase activity; positive regulation of telomere capping; positive regulation of telomere maintenance via telomerase; protein autophosphorylation; protein localization to ciliary transition zone; regulation of autophagy; regulation of cilium assembly; regulation of COPII vesicle coating
Reference #:  Q8TD08 (UniProtKB)
Alt. Names/Synonyms: ERK-7; ERK-8; ERK7; ERK8; extracellular regulated kinase 8 delta; extracellular signal regulated kinase 8; Extracellular signal-regulated kinase 7; Extracellular signal-regulated kinase 8; MAP kinase 15; MAPK 15; MAPK15; Mitogen-activated protein kinase 15; MK15
Gene Symbols: MAPK15
Molecular weight: 59,832 Da
Basal Isoelectric point: 9.17  Predict pI for various phosphorylation states
CST Pathways:  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  IL6 Signaling  |  Microtubule Dynamics  |  mTOR Signaling  |  Translation: eIF4E and p70S6K
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ERK7

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene