TUBB2A Tubulin is the major constituent of microtubules. It binds two moles of GTP, one at an exchangeable site on the beta chain and one at a non-exchangeable site on the alpha chain. Belongs to the tubulin family. High expression in brain, where it represents 30% of all beta-tubulins. Note: This description may include information from UniProtKB.
Protein type: Cytoskeletal; Motility/polarity/chemotaxis
Chromosomal Location of human Ortholog: 6p25.2
Cellular Component:  cytoplasm; intercellular bridge; microtubule; microtubule cytoskeleton; mitotic spindle
Molecular Function:  GTP binding; GTPase activity; metal ion binding; protein binding; structural constituent of cytoskeleton
Biological Process:  cerebral cortex development; microtubule cytoskeleton organization; mitotic cell cycle; neuron migration
Disease: Cortical Dysplasia, Complex, With Other Brain Malformations 5
Reference #:  Q13885 (UniProtKB)
Alt. Names/Synonyms: CDCBM5; class IIa beta-tubulin; dJ40E16.7; TBB2A; TUBB; TUBB2; TUBB2A; tubulin beta 2A class IIa; Tubulin beta class IIa; Tubulin beta-2A chain; tubulin, beta 2A; tubulin, beta polypeptide 2
Gene Symbols: TUBB2A
Molecular weight: 49,907 Da
Basal Isoelectric point: 4.78  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TUBB2A

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene