CLK3 Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex. May be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing and can cause redistribution of SR proteins from speckles to a diffuse nucleoplasmic distribution. Phosphorylates SRSF1 and SRSF3. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. Lammer subfamily. Endothelial cells. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CLK family; CMGC group; EC 2.7.12.1; Kinase, protein; Protein kinase, CMGC; Protein kinase, dual-specificity (non-receptor)
Chromosomal Location of Human Ortholog: 15q24.1
Cellular Component:  acrosomal vesicle; intermediate filament cytoskeleton; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; identical protein binding; protein binding; protein serine/threonine kinase activity; protein serine/threonine/tyrosine kinase activity; protein tyrosine kinase activity
Biological Process:  peptidyl-tyrosine phosphorylation; protein autophosphorylation; protein phosphorylation; regulation of RNA splicing
Reference #:  P49761 (UniProtKB)
Alt. Names/Synonyms: CDC-like kinase 3; CLK3; Dual specificity protein kinase CLK3; FLJ22858; PHCLK3; PHCLK3/152
Gene Symbols: CLK3
Molecular weight: 73,515 Da
Basal Isoelectric point: 9.94  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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CLK3

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein