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NFYB
Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors. Belongs to the NFYB/HAP3 subunit family. Note: This description may include information from UniProtKB.
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| Protein type: DNA-binding; Transcription factor |
| Chromosomal Location of human Ortholog: 12q23.3 |
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Cellular Component:
CCAAT-binding factor complex; chromatin; nucleoplasm; nucleus; protein-DNA complex; RNA polymerase II transcription regulator complex
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Molecular Function:
DNA binding; DNA-binding transcription activator activity, RNA polymerase II-specific; DNA-binding transcription factor activity; DNA-binding transcription factor activity, RNA polymerase II-specific; DNA-binding transcription factor binding; protein binding; protein heterodimerization activity; RNA polymerase II cis-regulatory region sequence-specific DNA binding; transcription cis-regulatory region binding
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Biological Process:
cellular response to leukemia inhibitory factor; histone H3-K4 trimethylation; positive regulation of transcription by RNA polymerase II; regulation of DNA-templated transcription; regulation of histone acetylation; regulation of transcription by RNA polymerase II
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Reference #:
P25208
(UniProtKB)
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Alt. Names/Synonyms: CAAT box DNA-binding protein subunit B; CBF-A; CBF-B; CCAAT-binding transcription factor subunit A; HAP3; NF-YB; NFYB; Nuclear transcription factor Y subunit B; Nuclear transcription factor Y subunit beta; nuclear transcription factor Y, beta; Transcription factor NF-Y, B subunit
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Gene Symbols: NFYB
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Molecular weight:
22,831 Da
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Basal Isoelectric point:
4.46
Predict pI for various phosphorylation states
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