eIF3-theta RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. (Microbial infection) Essential for the initiation of translation on type-1 viral ribosomal entry sites (IRESs), like for HCV, PV, EV71 or BEV translation. (Microbial infection) In case of FCV infection, plays a role in the ribosomal termination-reinitiation event leading to the translation of VP2. Belongs to the eIF-3 subunit A family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: RNA-binding; Translation; Translation initiation
Chromosomal Location of Human Ortholog: 1q55
Cellular Component:  cytosol; eukaryotic 43S preinitiation complex; eukaryotic 48S preinitiation complex; eukaryotic translation initiation factor 3 complex; eukaryotic translation initiation factor 3 complex, eIF3e; eukaryotic translation initiation factor 3 complex, eIF3m; microtubule; multi-eIF complex; nucleolus; nucleus; postsynaptic density
Molecular Function:  mRNA binding; protein binding; receptor tyrosine kinase binding; RNA binding
Biological Process:  formation of cytoplasmic translation initiation complex; IRES-dependent viral translational initiation; negative regulation of ERK1 and ERK2 cascade; translation reinitiation; viral translational termination-reinitiation
Reference #:  Q1JU68 (UniProtKB)
Alt. Names/Synonyms: eIF-3-theta; eIF3-theta; Eif3a; Eif3s10; Eukaryotic translation initiation factor 3 subunit 10; Eukaryotic translation initiation factor 3 subunit A; eukaryotic translation initiation factor 3, subunit 10 (theta); ZH12
Gene Symbols: Eif3a
Molecular weight: 163,196 Da
Basal Isoelectric point: 6.38  Predict pI for various phosphorylation states
CST Pathways:  Translational Control
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene