pleckstrin Major protein kinase C substrate of platelets. Note: This description may include information from UniProtKB.
Protein type: Lipid-binding
Chromosomal Location of Human Ortholog: 14q22
Cellular Component:  cytoplasm; plasma membrane; ruffle membrane
Molecular Function:  phosphatidylinositol-3,4-bisphosphate binding; protein homodimerization activity; protein kinase C binding
Biological Process:  actin cytoskeleton reorganization; cell projection organization; cortical actin cytoskeleton organization; hematopoietic progenitor cell differentiation; integrin-mediated signaling pathway; intracellular signal transduction; negative regulation of G protein-coupled receptor signaling pathway; negative regulation of inositol phosphate biosynthetic process; phosphatidylinositol metabolic process; phospholipase C-inhibiting G protein-coupled receptor signaling pathway; platelet aggregation; platelet degranulation; positive regulation of actin filament bundle assembly; positive regulation of actin filament depolymerization; positive regulation of inositol-polyphosphate 5-phosphatase activity; positive regulation of integrin activation; positive regulation of platelet activation; protein kinase C signaling; protein secretion by platelet; regulation of cell diameter; ruffle organization; thrombin-activated receptor signaling pathway; vesicle docking involved in exocytosis
Reference #:  Q4KM33 (UniProtKB)
Alt. Names/Synonyms: MGC112902; Pleckstrin; Plek
Gene Symbols: Plek
Molecular weight: 39,996 Da
Basal Isoelectric point: 8.52  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene