KIF2A Plus end-directed microtubule-dependent motor required for normal brain development. May regulate microtubule dynamics during axonal growth. Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles. Has microtubule depolymerization activity. Belongs to the kinesin-like protein family. MCAK/KIF2 subfamily. 4 isoforms of the human protein are produced by alternative splicing. Note: This description may include information from UniProtKB.
Protein type: Microtubule-binding; Motor
Chromosomal Location of Human Ortholog: 2q13
Cellular Component:  centriolar subdistal appendage; centriole; centrosome; cytoplasm; kinesin complex; microtubule; nuclear body; nucleolus; nucleus; sperm principal piece; spindle microtubule; spindle pole
Molecular Function:  ATP binding; ATPase activity; microtubule binding; microtubule motor activity; protein kinase binding
Biological Process:  cell differentiation; cell division; microtubule cytoskeleton organization; microtubule-based movement; mitotic spindle assembly; mitotic spindle organization; nervous system development; regulation of cell migration
Reference #:  Q9WV63 (UniProtKB)
Alt. Names/Synonyms: Kif2; Kif2a; kinesin family member 2A; kinesin heavy chain family, member 2; kinesin heavy chain member 2; Kinesin-2; Kinesin-like protein KIF2A
Gene Symbols: Kif2a
Molecular weight: 79,792 Da
Basal Isoelectric point: 6.28  Predict pI for various phosphorylation states
Select Structure to View Below

KIF2A

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  Reactome  |  BioGPS  |  Pfam  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene