IWS1
Transcription factor which plays a key role in defining the composition of the RNA polymerase II (RNAPII) elongation complex and in modulating the production of mature mRNA transcripts. Acts as an assembly factor to recruit various factors to the RNAPII elongation complex and is recruited to the complex via binding to the transcription elongation factor SUPT6H bound to the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2) to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. Belongs to the IWS1 family. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Transcription factor |
Chromosomal Location of rat Ortholog: 18p12 |
Cellular Component:
nucleoplasm; nucleus
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Biological Process:
chromatin remodeling; mRNA processing; poly(A)+ mRNA export from nucleus; regulation of mRNA export from nucleus; regulation of mRNA processing; RNA splicing; transcription elongation-coupled chromatin remodeling
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Reference #:
Q3SWT4
(UniProtKB)
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Alt. Names/Synonyms: Iws1; IWS1 homolog (S. cerevisiae); IWS1-like protein; Iws1l; MGC124986; Protein IWS1 homolog; RGD1304762
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Gene Symbols: Iws1
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Molecular weight:
85,448 Da
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Basal Isoelectric point:
4.61
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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