HMGCS1 This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the thiolase-like superfamily. HMG-CoA synthase family. Note: This description may include information from UniProtKB.
Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase
Chromosomal Location of rat Ortholog: 2q15
Cellular Component:  cytosol
Molecular Function:  drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity
Biological Process:  acetyl-CoA metabolic process; brain development; cellular response to cholesterol; cellular response to follicle-stimulating hormone stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to organic cyclic compound; cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; liver development; male gonad development; response to cholesterol; response to drug; response to gonadotropin; response to hormone; response to low light intensity stimulus; response to organic cyclic compound; response to organic substance; response to purine-containing compound; response to tellurium ion; response to vitamin E
Reference #:  P17425 (UniProtKB)
Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMCS1; HMG-CoA synthase; Hmgcs; Hmgcs1; Hydroxymethylglutaryl-CoA synthase, cytoplasmic
Gene Symbols: Hmgcs1
Molecular weight: 57,434 Da
Basal Isoelectric point: 5.58  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene