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HMGCS1
This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. Belongs to the thiolase-like superfamily. HMG-CoA synthase family. Note: This description may include information from UniProtKB.
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| Protein type: Amino Acid Metabolism - valine, leucine and isoleucine degradation; Carbohydrate Metabolism - butanoate; EC 2.3.3.10; Lipid Metabolism - synthesis and degradation of ketone bodies; Secondary Metabolites Metabolism - terpenoid backbone biosynthesis; Transferase |
| Chromosomal Location of rat Ortholog: 2q15 |
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Cellular Component:
cytosol
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Molecular Function:
drug binding; hydroxymethylglutaryl-CoA synthase activity; isomerase activity; organic acid binding; protein homodimerization activity
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Biological Process:
acetyl-CoA metabolic process; brain development; cellular response to cholesterol; cellular response to follicle-stimulating hormone stimulus; cellular response to low-density lipoprotein particle stimulus; cellular response to organic cyclic compound; cholesterol biosynthetic process; farnesyl diphosphate biosynthetic process, mevalonate pathway; liver development; male gonad development; response to cholesterol; response to drug; response to gonadotropin; response to hormone; response to low light intensity stimulus; response to organic cyclic compound; response to organic substance; response to purine-containing compound; response to tellurium ion; response to vitamin E
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Reference #:
P17425
(UniProtKB)
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Alt. Names/Synonyms: 3-hydroxy-3-methylglutaryl coenzyme A synthase; 3-hydroxy-3-methylglutaryl-Coenzyme A synthase 1 (soluble); HMCS1; HMG-CoA synthase; Hmgcs; Hmgcs1; Hydroxymethylglutaryl-CoA synthase, cytoplasmic
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Gene Symbols: Hmgcs1
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Molecular weight:
57,434 Da
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Basal Isoelectric point:
5.58
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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