CDK11B Plays multiple roles in cell cycle progression, cytokinesis and apoptosis. Involved in pre-mRNA splicing in a kinase activity-dependent manner. Isoform 7 may act as a negative regulator of normal cell cycle progression. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed ubiquitously. Some evidence of isoform-specific tissue distribution. 10 alternative splicing and alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Apoptosis; CDK family; CDK/PITSLRE subfamily; CMGC group; Cell cycle regulation; EC 2.7.11.22; Kinase, protein; Motility/polarity/chemotaxis; PITSLRE subfamily; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 1p36.33
Cellular Component:  cytoplasm; nucleus
Molecular Function:  ATP binding; protein binding; protein kinase activity; protein serine/threonine kinase activity
Biological Process:  apoptotic process; mitotic cell cycle; protein phosphorylation; regulation of cell cycle; regulation of cell growth; regulation of mRNA processing; regulation of transcription, DNA-templated
Reference #:  P21127 (UniProtKB)
Alt. Names/Synonyms: CD11B; CDC-related protein kinase p58; CDC2L1; CDC2L2; CDK11; CDK11-p110; CDK11-p46; CDK11-p58; CDK11B; CDK11p58; cell division cycle 2-like 1 (PITSLRE proteins); cell division cycle 2-like 2 (PITSLRE proteins); cell division cycle 2-like protein kinase 1; cell division protein kinase 11B; CLK-1; cyclin dependent kinase 11B; Cyclin-dependent kinase 11B; FLJ59152; galactosyltransferase-associated protein kinase p58/GTA; p58; p58 CLK-1; p58CDC2L1; p58CLK-1; PITSLRE; PITSLRE serine/threonine-protein kinase CDC2L1; PITSLREA; PK58
Gene Symbols: CDK11B
Molecular weight: 92,707 Da
Basal Isoelectric point: 5.45  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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CDK11B

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene