ATP8B3 iso4 P4-ATPase flippase which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. May be responsible for the maintenance of asymmetric distribution of phosphatidylserine (PS) in spermatozoa membranes. Involved in acrosome reactions and binding of spermatozoa to zona pellucida. Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily. Isoform 3 was only detected in testis. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 3.6.3.1; Hydrolase; Membrane protein, integral; Membrane protein, multi-pass; Transporter; Transporter, ion channel
Chromosomal Location of Human Ortholog: 19p13.3
Cellular Component:  acrosomal membrane; endoplasmic reticulum membrane; integral component of membrane
Molecular Function:  ATP binding; magnesium ion binding
Biological Process:  binding of sperm to zona pellucida
Reference #:  Q6ZUX8 (UniProtKB)
Alt. Names/Synonyms: aminophospholipid translocase ATP8B3; ATP8B3; ATP8B3 iso4; ATPase phospholipid transporting 8B3; ATPase, aminophospholipid transporter, class I, type 8B, member 3; ATPase, class I, type 8B, member 3; ATPIK; cDNA FLJ43235 fis, clone HCHON2004007, highly similar to Potential phospholipid-transporting ATPase IK; cDNA FLJ43235 fis, clone HCHON2004007, highly similar to Potential phospholipid-transporting ATPase IK (EC 3.6.3.13); phospholipid-transporting ATPase IK; potential phospholipid-transporting ATPase IK; probable phospholipid-transporting ATPase IK
Gene Symbols: ATP8B3
Molecular weight: 66,176 Da
Basal Isoelectric point: 9.41  Predict pI for various phosphorylation states
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ATP8B3 iso4

Protein Structure Not Found.

Cross-references to other databases:  cBioPortal  |  Wikipedia  |  Pfam  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene