CDK12 Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Ubiquitously expressed. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing; Spliceosome
Chromosomal Location of human Ortholog: 17q12
Cellular Component:  cyclin K-CDK12 complex; fibrillar center; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; cyclin binding; protein binding; protein kinase activity; protein kinase binding; RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process:  mRNA processing; negative regulation of stem cell differentiation; phosphorylation of RNA polymerase II C-terminal domain; protein autophosphorylation; regulation of cell cycle; regulation of MAP kinase activity; regulation of RNA splicing; RNA splicing
Reference #:  Q9NYV4 (UniProtKB)
Alt. Names/Synonyms: Cdc2-related kinase, arginine/serine-rich; CDC2-related protein kinase 7; CDK12; Cell division cycle 2-related protein kinase 7; Cell division protein kinase 12; CRK7; CRKR; CRKRS; cyclin dependent kinase 12; Cyclin-dependent kinase 12; hCDK12; KIAA0904
Gene Symbols: CDK12
Molecular weight: 164,155 Da
Basal Isoelectric point: 9.46  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein