CDK13 Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC 2.7.11.22; EC 2.7.11.23; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing
Chromosomal Location of human Ortholog: 7p14.1
Cellular Component:  cyclin K-CDK13 complex; cytosol; extracellular region; ficolin-1-rich granule lumen; Golgi apparatus; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm
Molecular Function:  ATP binding; cyclin binding; protein binding; protein kinase activity; protein kinase binding; RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process:  alternative mRNA splicing, via spliceosome; hemopoiesis; multicellular organism development; negative regulation of stem cell differentiation; neutrophil degranulation; phosphorylation of RNA polymerase II C-terminal domain; positive regulation of cell proliferation; regulation of mitotic nuclear division; viral process
Reference #:  Q14004 (UniProtKB)
Alt. Names/Synonyms: CDC2-related protein kinase 5; CDC2L; CDC2L5; CDK13; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHDFIDD; CHED; Cholinesterase-related cell division controller; cyclin dependent kinase 13; Cyclin-dependent kinase 13; FLJ35215; hCDK13; KIAA1791
Gene Symbols: CDK13
Molecular weight: 164,923 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
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CDK13

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein