CDK13 Cyclin-dependent kinase which displays CTD kinase activity and is required for RNA splicing. Has CTD kinase activity by hyperphosphorylating the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit RPB1, thereby acting as a key regulator of transcription elongation. Required for RNA splicing, probably by phosphorylating SRSF1/SF2. Required during hematopoiesis. In case of infection by HIV-1 virus, interacts with HIV-1 Tat protein acetylated at 'Lys-50' and 'Lys-51', thereby increasing HIV-1 mRNA splicing and promoting the production of the doubly spliced HIV-1 protein Nef. Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. Expressed in fetal brain, liver, muscle and in adult brain. Also expressed in neuroblastoma and glioblastoma tumors. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CDK family; CDK/CRK7 subfamily; CMGC group; CRK7 subfamily; Cell cycle regulation; EC; EC; Kinase, protein; Motility/polarity/chemotaxis; Protein kinase, CMGC; Protein kinase, Ser/Thr (non-receptor); RNA splicing
Chromosomal Location of human Ortholog: 7p14.1
Cellular Component:  cyclin K-CDK13 complex; cyclin/CDK positive transcription elongation factor complex; cytosol; extracellular region; ficolin-1-rich granule lumen; Golgi apparatus; nuclear cyclin-dependent protein kinase holoenzyme complex; nuclear speck; nucleoplasm; nucleus
Molecular Function:  ATP binding; cyclin binding; protein binding; protein kinase activity; protein kinase binding; protein serine kinase activity; RNA polymerase II CTD heptapeptide repeat kinase activity
Biological Process:  alternative mRNA splicing, via spliceosome; hemopoiesis; negative regulation of stem cell differentiation; positive regulation of transcription by RNA polymerase II; positive regulation of transcription elongation by RNA polymerase II; protein phosphorylation; regulation of cell cycle; regulation of signal transduction
Reference #:  Q14004 (UniProtKB)
Alt. Names/Synonyms: CDC2-related protein kinase 5; CDC2L; CDC2L5; CDK13; Cell division cycle 2-like protein kinase 5; Cell division protein kinase 13; CHDFIDD; CHED; Cholinesterase-related cell division controller; cyclin dependent kinase 13; Cyclin-dependent kinase 13; FLJ35215; hCDK13; KIAA1791
Gene Symbols: CDK13
Molecular weight: 164,923 Da
Basal Isoelectric point: 9.71  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

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