ICOS
Enhances all basic T-cell responses to a foreign antigen, namely proliferation, secretion of lymphokines, up-regulation of molecules that mediate cell-cell interaction, and effective help for antibody secretion by B-cells. Essential both for efficient interaction between T and B-cells and for normal antibody responses to T-cell dependent antigens. Does not up-regulate the production of interleukin-2, but superinduces the synthesis of interleukin-10. Prevents the apoptosis of pre-activated T-cells. Plays a critical role in CD40-mediated class switching of immunoglobin isotypes. Activated T-cells. Highly expressed on tonsillar T-cells, which are closely associated with B-cells in the apical light zone of germinal centers, the site of terminal B-cell maturation. Expressed at lower levels in thymus, lung, lymph node and peripheral blood leukocytes. Expressed in the medulla of fetal and newborn thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: Membrane protein, integral |
Chromosomal Location of mouse Ortholog: 1 C2|1 30.6 cM |
Cellular Component:
external side of plasma membrane; membrane; plasma membrane
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Molecular Function:
protein binding
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Biological Process:
cell-cell adhesion; T cell costimulation; T cell tolerance induction
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Reference #:
Q9WVS0
(UniProtKB)
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Alt. Names/Synonyms: Activation-inducible lymphocyte immunomediatory molecule; Ailim; CCLP; CD278; CD28 and CTLA-4-like protein; CD28-related protein 1; CH29-120A16.4; CRP-1; ICOS; inducible T cell co-stimulator; Inducible T-cell costimulator; Ly115; OTTMUSP00000002206; OTTMUSP00000002207
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Gene Symbols: Icos
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Molecular weight:
22,709 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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