OBSCN Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle. Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1. Binds (via the PH domain) strongly to phosphatidylinositol 3,4-bisphosphate (PtdIns(3,4)P2) and phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2), and to a lesser extent to phosphatidylinositol 3-phosphate (PtdIns(3)P), phosphatidylinositol 4-phosphate (PtdIns(4)P), phosphatidylinositol 5-phosphate (PtdIns(5)P) and phosphatidylinositol 3,4,5-trisphosphate (PtdIns(3,4,5)P3). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 5 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.

Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family

Chromosomal Location of human Ortholog: 1q42.13

Cellular Component: cell-cell junction; cytosol; M band; myofibril; nuclear body; plasma membrane; sarcolemma; Z disc

Molecular Function: ankyrin binding; ATP binding; calmodulin binding; cell adhesion molecule binding; guanyl-nucleotide exchange factor activity; metal ion binding; phosphatidylinositol-3,4,5-trisphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; phosphatidylinositol-3-phosphate binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylinositol-4-phosphate binding; phosphatidylinositol-5-phosphate binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity; structural constituent of muscle; titin binding

Biological Process: cell-cell adhesion; protein localization to M-band; protein phosphorylation; regulation of catalytic activity; regulation of small GTPase mediated signal transduction; sarcomere organization

Reference #: Q5VST9 (UniProtKB)

Alt. Names/Synonyms: ARHGEF30; DKFZp666E245; FLJ14124; KIAA1556; KIAA1639; MGC120409; MGC120410; MGC120411; MGC120412; MGC138590; OBSCN; Obscurin; obscurin, cytoskeletal calmodulin and titin-interacting RhoGEF; obscurin, myosin light chain kinase; Obscurin-MLCK; Obscurin-myosin light chain kinase; Obscurin-RhoGEF; UNC89

Gene Symbols: OBSCN

Molecular weight: 868,484 Da

Basal Isoelectric point: 5.69 Predict pI for various phosphorylation states

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OBSCN

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