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SPEG
Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family |
| Chromosomal Location of mouse Ortholog: 1 C4|1 38.88 cM |
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Cellular Component:
nucleus
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Molecular Function:
ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
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Biological Process:
cardiac muscle cell development; cell differentiation; circulatory system development; in utero embryonic development; muscle cell differentiation; phosphorylation; protein phosphorylation; respiratory system development
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Reference #:
Q62407
(UniProtKB)
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Alt. Names/Synonyms: aortic preferentially expressed gene 1; Aortic preferentially expressed protein 1; Ape; APEG-1; Apeg1; AW125581; BPE; BPEG; D1Bwg1450e; Kiaa1297; mKIAA1297; OTTMUSP00000020922; SPE; Speg; SPEG complex locus; SPEGalpha; SPEGb; SPEGbeta; Striated muscle-specific serine/threonine-protein kinase
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Gene Symbols: Speg
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Molecular weight:
354,343 Da
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Basal Isoelectric point:
8.53
Predict pI for various phosphorylation states
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