SPEG Isoform 3 may have a role in regulating the growth and differentiation of arterial smooth muscle cells. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Isoform 1 is preferentially expressed in striated muscle. Non-kinase form such as isoform 3 is predominantly expressed in the aorta. Isoform 3 appears to be expressed only in highly differentiated ASMC in normal vessel walls and down-regulated in dedifferentiated ASMC in vivo. In response to vascular injuries ASMC dedifferentiate and change from a quiescent and contractile phenotype to a proliferative and synthetic phenotype. This proliferation of vascular smooth muscle cells is one of the most prominent features of atherosclerosis. 4 human isoforms generated by alternative promoter usage or alternative splicing have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trio family
Chromosomal Location of Human Ortholog: 1 C4|1 38.88 cM
Cellular Component:  nucleus
Molecular Function:  ATP binding; kinase activity; nucleotide binding; protein kinase activity; protein serine/threonine kinase activity; transferase activity
Biological Process:  cardiac muscle cell development; cardiovascular system development; cell differentiation; in utero embryonic development; muscle cell differentiation; phosphorylation; respiratory system development
Reference #:  Q62407 (UniProtKB)
Alt. Names/Synonyms: aortic preferentially expressed gene 1; Aortic preferentially expressed protein 1; Ape; APEG-1; Apeg1; AW125581; BPE; BPEG; D1Bwg1450e; Kiaa1297; mKIAA1297; OTTMUSP00000020922; SPE; Speg; SPEG complex locus; SPEGalpha; SPEGb; SPEGbeta; Striated muscle-specific serine/threonine-protein kinase
Gene Symbols: Speg
Molecular weight: 354,343 Da
Basal Isoelectric point: 8.53  Predict pI for various phosphorylation states
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SPEG

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene