TXNRD3 Displays thioredoxin reductase, glutaredoxin and glutathione reductase activities. Catalyzes disulfide bond isomerization. Promotes disulfide bond formation between GPX4 and various sperm proteins and may play a role in sperm maturation by promoting formation of sperm structural components. Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. Note: This description may include information from UniProtKB.
Protein type: EC; Oxidoreductase
Chromosomal Location of human Ortholog: 3q21.3
Cellular Component:  endoplasmic reticulum; nucleus
Molecular Function:  electron transfer activity; flavin adenine dinucleotide binding; protein disulfide oxidoreductase activity; thioredoxin-disulfide reductase activity
Biological Process:  cell differentiation; cell redox homeostasis; cellular oxidant detoxification; electron transport chain; multicellular organism development; spermatogenesis
Reference #:  Q86VQ6 (UniProtKB)
Alt. Names/Synonyms: selenoprotein TXNRD3; TGR; Thioredoxin and glutathione reductase; thioredoxin glutathione reductase; thioredoxin reductase 2; thioredoxin reductase 2 intronic transcript 1; Thioredoxin reductase 3; thioredoxin reductase 3 intronic transcript 1; thioredoxin reductase 3 neighbor gene protein; thioredoxin reductase 3 new transcript 1; Thioredoxin reductase TR2; TR2; TR2IT1; TRXR3; TXNRD3; TXNRD3 neighbor gene protein; TXNRD3IT1; TXNRD3NB; TXNRD3NT1
Gene Symbols: TXNRD3
Molecular weight: 70,683 Da
Basal Isoelectric point: 8.13  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene