SPIRE2 Acts as an actin nucleation factor, remains associated with the slow-growing pointed end of the new filament. Involved in intracellular vesicle transport along actin fibers, providing a novel link between actin cytoskeleton dynamics and intracellular transport. Required for asymmetric spindle positioning and asymmetric cell division during meiosis. Required for normal formation of the cleavage furrow and for polar body extrusion during female germ cell meiosis. Also acts in the nucleus: together with SPIRE1 and SPIRE2, promotes assembly of nuclear actin filaments in response to DNA damage in order to facilitate movement of chromatin and repair factors after DNA damage. Belongs to the spire family. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Unknown function
Chromosomal Location of Human Ortholog: 16q24.3
Cellular Component:  cell cortex; cytoplasmic vesicle membrane; cytoskeleton; cytosol
Molecular Function:  actin binding
Biological Process:  actin cytoskeleton organization; actin nucleation; cleavage furrow formation; establishment of meiotic spindle localization; formin-nucleated actin cable assembly; intracellular transport; polar body extrusion after meiotic divisions; positive regulation of double-strand break repair; protein transport; vesicle-mediated transport
Reference #:  Q8WWL2 (UniProtKB)
Alt. Names/Synonyms: KIAA1832; MGC117166; Protein spire homolog 2; Spir-2; SPIR2; spire homolog 2 (Drosophila); SPIRE2
Gene Symbols: SPIRE2
Molecular weight: 79,671 Da
Basal Isoelectric point: 7.75  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene