TRB2 Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Highly expressed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family
Chromosomal Location of human Ortholog: 2p24.3
Cellular Component:  cytoplasm; cytoskeleton
Molecular Function:  protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity
Biological Process:  negative regulation of fat cell differentiation; negative regulation of interleukin-10 biosynthetic process; negative regulation of protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of MAP kinase activity
Reference #:  Q92519 (UniProtKB)
Alt. Names/Synonyms: C5FW; FLJ57420; GS3955; TRB-2; TRB2; TRIB2; Tribbles homolog 2; tribbles homolog 2 (Drosophila); tribbles pseudokinase 2
Gene Symbols: TRIB2
Molecular weight: 38,801 Da
Basal Isoelectric point: 5.77  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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TRB2

Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene