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TRB2
Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Highly expressed in peripheral blood leukocytes. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family |
| Chromosomal Location of human Ortholog: 2p24.3 |
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Cellular Component:
cytoplasm; cytoskeleton; nucleus
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Molecular Function:
mitogen-activated protein kinase kinase binding; nucleotide binding; protein binding; protein kinase activity; protein kinase inhibitor activity; RNA polymerase II-specific DNA-binding transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity
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Biological Process:
negative regulation of fat cell differentiation; negative regulation of interleukin-10 production; negative regulation of protein kinase activity; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; protein phosphorylation; regulation of MAP kinase activity
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Reference #:
Q92519
(UniProtKB)
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Alt. Names/Synonyms: C5FW; FLJ57420; GS3955; TRB-2; TRB2; TRIB2; Tribbles homolog 2; tribbles homolog 2 (Drosophila); tribbles pseudokinase 2
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Gene Symbols: TRIB2
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Molecular weight:
38,801 Da
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Basal Isoelectric point:
5.77
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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