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TRB1
Adapter protein involved in protein degradation by interacting with COP1 ubiquitin ligase. The COP1-binding motif is masked by autoinhibitory interactions with the protein kinase domain. Serves to alter COP1 substrate specificity by directing the activity of COP1 toward CEBPA. Binds selectively the recognition sequence of CEBPA. Regulates myeloid cell differentiation by altering the expression of CEBPA in a COP1-dependent manner. Controls macrophage, eosinophil and neutrophil differentiation via the COP1-binding domain. Interacts with MAPK kinases and regulates activation of MAP kinases, but has no kinase activity. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Tribbles subfamily. Expressed in most human tissues with the highest levels in skeletal muscle, thyroid gland, pancreas, peripheral blood leukocytes, and bone marrow. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Trbl family |
| Chromosomal Location of human Ortholog: 8q24.13 |
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Cellular Component:
cytoplasm; nucleus
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Molecular Function:
mitogen-activated protein kinase kinase binding; protein binding; protein kinase inhibitor activity; transcription factor binding; ubiquitin protein ligase binding; ubiquitin-protein transferase regulator activity
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Biological Process:
JNK cascade; negative regulation of DNA-binding transcription factor activity; negative regulation of lipopolysaccharide-mediated signaling pathway; negative regulation of neutrophil differentiation; negative regulation of protein kinase activity; negative regulation of smooth muscle cell migration; negative regulation of smooth muscle cell proliferation; positive regulation of eosinophil differentiation; positive regulation of macrophage differentiation; positive regulation of proteasomal ubiquitin-dependent protein catabolic process; regulation of MAP kinase activity; response to lipopolysaccharide
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Reference #:
Q96RU8
(UniProtKB)
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Alt. Names/Synonyms: C8FW; G-protein-coupled receptor induced protein; G-protein-coupled receptor-induced gene 2 protein; G-protein-coupled receptor-induced protein 2; GIG-2; GIG2; phosphoprotein regulated by mitogenic pathways; SKIP1; TRB-1; TRB1; TRIB1; Tribbles homolog 1; tribbles homolog 1 (Drosophila); tribbles pseudokinase 1; tribbles-like protein 1
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Gene Symbols: TRIB1
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Molecular weight:
41,009 Da
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Basal Isoelectric point:
6.86
Predict pI for various phosphorylation states
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