Pim1 Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation and thus providing a selective advantage in tumorigenesis. Exerts its oncogenic activity through: the regulation of MYC transcriptional activity, the regulation of cell cycle progression and by phosphorylation and inhibition of proapoptotic proteins (BAD, MAP3K5, FOXO3). Phosphorylation of MYC leads to an increase of MYC protein stability and thereby an increase of transcriptional activity. The stabilization of MYC exerted by PIM1 might explain partly the strong synergism between these two oncogenes in tumorigenesis. Mediates survival signaling through phosphorylation of BAD, which induces release of the anti-apoptotic protein Bcl-X(L)/BCL2L1. Phosphorylation of MAP3K5, an other proapoptotic protein, by PIM1, significantly decreases MAP3K5 kinase activity and inhibits MAP3K5-mediated phosphorylation of JNK and JNK/p38MAPK subsequently reducing caspase-3 activation and cell apoptosis. Stimulates cell cycle progression at the G1-S and G2-M transitions by phosphorylation of CDC25A and CDC25C. Phosphorylation of CDKN1A, a regulator of cell cycle progression at G1, results in the relocation of CDKN1A to the cytoplasm and enhanced CDKN1A protein stability. Promote cell cycle progression and tumorigenesis by down-regulating expression of a regulator of cell cycle progression, CDKN1B, at both transcriptional and post-translational levels. Phosphorylation of CDKN1B,induces 14-3-3-proteins binding, nuclear export and proteasome-dependent degradation. May affect the structure or silencing of chromatin by phosphorylating HP1 gamma/CBX3. Acts also as a regulator of homing and migration of bone marrow cells involving functional interaction with the CXCL12-CXCR4 signaling axis. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. Expressed primarily in cells of the hematopoietic and germline lineages. Isoform 1 and isoform 2 are both expressed in prostate cancer cell lines. 2 alternative initiation human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC 2.7.11.1; Kinase, protein; Oncoprotein; PIM family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 20p12
Cellular Component:  cytoplasm; cytosol; nucleolus; nucleus; plasma membrane
Molecular Function:  ATP binding; manganese ion binding; protein serine/threonine kinase activity; ribosomal small subunit binding; transcription factor binding
Biological Process:  apoptotic process; cell proliferation; hyaluronan metabolic process; negative regulation of apoptotic process; negative regulation of DNA-binding transcription factor activity; positive regulation of cardiac muscle cell proliferation; positive regulation of cardioblast proliferation; positive regulation of cyclin-dependent protein serine/threonine kinase activity; positive regulation of transcription, DNA-templated; protein autophosphorylation; protein phosphorylation; protein stabilization; regulation of hematopoietic stem cell proliferation; vitamin D receptor signaling pathway
Reference #:  P26794 (UniProtKB)
Alt. Names/Synonyms: Pim-1; pim-1 oncogene; Pim1; Proto-oncogene serine/threonine-protein kinase pim-1; proviral integration site 1; Serine/threonine-protein kinase pim-1
Gene Symbols: Pim1
Molecular weight: 35,631 Da
Basal Isoelectric point: 5.81  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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Pim1

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Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene