Pim3 Proto-oncogene with serine/threonine kinase activity that can prevent apoptosis, promote cell survival and protein translation. May contribute to tumorigenesis through: the delivery of survival signaling through phosphorylation of BAD which induces release of the anti-apoptotic protein Bcl-X(L), the regulation of cell cycle progression, protein synthesis and by regulation of MYC transcriptional activity. Additionally to this role on tumorigenesis, can also negatively regulate insulin secretion by inhibiting the activation of MAPK1/3 (ERK1/2), through SOCS6. Involved also in the control of energy metabolism and regulation of AMPK activity in modulating MYC and PPARGC1A protein levels and cell growth. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. Detected in various tissues, including the heart, brain, lung, kidney, spleen, placenta, skeletal muscle, and peripheral blood leukocytes. Not found or barely expressed in the normal adult endoderm-derived organs such as colon, thymus, liver, or small intestine. However, expression is augmented in premalignant and malignant lesions of these organs. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; Oncoprotein; PIM family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 7q34
Cellular Component:  cytoplasm; cytosol
Molecular Function:  ATP binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cellular response to forskolin; negative regulation of apoptotic process; negative regulation of insulin secretion involved in cellular response to glucose stimulus; protein autophosphorylation; protein phosphorylation; regulation of mitotic cell cycle
Reference #:  O70444 (UniProtKB)
Alt. Names/Synonyms: Kid1; Kinase induced by depolarization; pim-3 oncogene; Pim3; Protein kinase Kid-1; proviral integration site 3; serine threonine kinase pim3; serine/threonine protein kinase pim-3; Serine/threonine-protein kinase pim-3
Gene Symbols: Pim3
Molecular weight: 36,002 Da
Basal Isoelectric point: 5.53  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  UniProtKB  |  Entrez-Gene  |  GenPept