PHKG2 Catalytic subunit of the phosphorylase b kinase (PHK), which mediates the neural and hormonal regulation of glycogen breakdown (glycogenolysis) by phosphorylating and thereby activating glycogen phosphorylase. May regulate glycogeneolysis in the testis. In vitro, phosphorylates PYGM. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; EC; Kinase, protein; PHK family; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 16p11.2
Cellular Component:  cytosol; phosphorylase kinase complex
Molecular Function:  ATP binding; enzyme binding; phosphorylase kinase activity; protein binding; protein serine/threonine kinase activity; tau-protein kinase activity
Biological Process:  generation of precursor metabolites and energy; glycogen biosynthetic process; glycogen catabolic process; glycogen metabolic process; positive regulation of glycogen catabolic process; protein phosphorylation
Disease: Glycogen Storage Disease Ixc
Reference #:  P15735 (UniProtKB)
Alt. Names/Synonyms: GSD9C; PHK-gamma-LT; PHK-gamma-T; PHKG2; Phosphorylase b kinase gamma catalytic chain, liver/testis isoform; Phosphorylase b kinase gamma catalytic chain, testis/liver isoform; phosphorylase kinase catalytic subunit gamma 2; phosphorylase kinase gamma subunit 2; Phosphorylase kinase subunit gamma-2; phosphorylase kinase, gamma 2 (testis); Phosphorylase kinase, gamma 2 (testis/liver); PSK-C3; serine/threonine-protein kinase PHKG2
Gene Symbols: PHKG2
Molecular weight: 46,442 Da
Basal Isoelectric point: 5.95  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene