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CNOT6L
Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. Belongs to the CCR4/nocturin family. Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.13.4; Hydrolase |
| Chromosomal Location of human Ortholog: 4q21.1 |
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Cellular Component:
CCR4-NOT complex; cytoplasm; cytosol; nucleus
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Molecular Function:
3'-5'-exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding
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Biological Process:
mRNA processing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of cell population proliferation; positive regulation of cytoplasmic mRNA processing body assembly; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA-mediated gene silencing
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Reference #:
Q96LI5
(UniProtKB)
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Alt. Names/Synonyms: Carbon catabolite repressor protein 4 homolog B; CCR4-NOT transcription complex subunit 6 like; CCR4-NOT transcription complex subunit 6-like; CCR4-NOT transcription complex, subunit 6-like; CCR4B; CNO6L; CNOT6L
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Gene Symbols: CNOT6L
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Molecular weight:
63,001 Da
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Basal Isoelectric point:
6.26
Predict pI for various phosphorylation states
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