CNOT6L Has 3'-5' poly(A) exoribonuclease activity for synthetic poly(A) RNA substrate. Catalytic component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in the deadenylation-dependent degradation of mRNAs through the 3'-UTR AU-rich element-mediated mechanism. Involved in deadenylation-dependent degradation of CDKN1B mRNA. Its mRNA deadenylase activity can be inhibited by TOB1. Mediates cell proliferation and cell survival and prevents cellular senescence. Belongs to the CCR4/nocturin family. Highly expressed in placenta, skeletal muscle, pancreas, testis and leukocytes. Weakly expressed in heart, spleen and thymus. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Hydrolase
Chromosomal Location of human Ortholog: 4q21.1
Cellular Component:  CCR4-NOT complex; cytoplasm; cytosol; nucleus
Molecular Function:  3'-5'-exoribonuclease activity; metal ion binding; poly(A)-specific ribonuclease activity; protein binding
Biological Process:  mRNA processing; nuclear-transcribed mRNA poly(A) tail shortening; positive regulation of cell population proliferation; positive regulation of cytoplasmic mRNA processing body assembly; RNA phosphodiester bond hydrolysis, exonucleolytic; RNA-mediated gene silencing
Reference #:  Q96LI5 (UniProtKB)
Alt. Names/Synonyms: Carbon catabolite repressor protein 4 homolog B; CCR4-NOT transcription complex subunit 6 like; CCR4-NOT transcription complex subunit 6-like; CCR4-NOT transcription complex, subunit 6-like; CCR4B; CNO6L; CNOT6L
Gene Symbols: CNOT6L
Molecular weight: 63,001 Da
Basal Isoelectric point: 6.26  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene