DCAMKL2 Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in the brain, heart and eyes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; DCAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 4q31.23-q31.3
Cellular Component:  cytoplasm; cytoskeleton
Molecular Function:  ATP binding; microtubule binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  hippocampus development; intracellular signal transduction; microtubule cytoskeleton organization; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; protein localization to nucleus; pyramidal neuron development
Reference #:  Q8N568 (UniProtKB)
Alt. Names/Synonyms: CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2; DKFZp761I032; doublecortin and CaM kinase-like 2; Doublecortin domain-containing protein 3B; doublecortin like kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; MGC45428; Serine/threonine-protein kinase DCLK2
Gene Symbols: DCLK2
Molecular weight: 83,606 Da
Basal Isoelectric point: 8.63  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein