DCAMKL2
Protein kinase with a significantly reduced C(a2+)/CAM affinity and dependence compared to other members of the CaMK family. May play a role in the down-regulation of CRE-dependent gene activation probably by phosphorylation of the CREB coactivator CRTC2/TORC2 and the resulting retention of TORC2 in the cytoplasm. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in the brain, heart and eyes. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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Protein type: CAMK group; DCAMKL family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
Chromosomal Location of human Ortholog: 4q31.23-q31.3 |
Cellular Component:
cytoplasm; cytoskeleton
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Molecular Function:
ATP binding; microtubule binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
hippocampus development; intracellular signal transduction; microtubule cytoskeleton organization; negative regulation of protein localization to nucleus; peptidyl-serine phosphorylation; protein localization to nucleus; pyramidal neuron development
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Reference #:
Q8N568
(UniProtKB)
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Alt. Names/Synonyms: CaMK-like CREB regulatory kinase 2; CL2; CLICK-II; CLICK2; CLIK2; DCAMKL2; DCDC3; DCDC3B; DCK2; DCLK2; DKFZp761I032; doublecortin and CaM kinase-like 2; Doublecortin domain-containing protein 3B; doublecortin like kinase 2; Doublecortin-like and CAM kinase-like 2; Doublecortin-like kinase 2; MGC45428; Serine/threonine-protein kinase DCLK2
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Gene Symbols: DCLK2
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Molecular weight:
83,606 Da
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Basal Isoelectric point:
8.63
Predict pI for various phosphorylation states
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