ATAD5 Involved in DNA damage response. Involved in a RAD9A-related damage checkpoint, a pathway that is important in determining whether DNA damage is compatible with cell survival or whether it requires cell elimination by apoptosis. Modulates the RAD9A interaction with BCL2 and thereby induces DNA damages-induced apoptosis. Belongs to the AAA ATPase family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Chromosomal Location of Human Ortholog: 17q11.2
Cellular Component:  Elg1 RFC-like complex
Molecular Function:  ATP binding; DNA clamp unloader activity; protein binding
Biological Process:  B cell proliferation; DNA clamp unloading; intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; isotype switching; negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator; nuclear DNA replication; nucleic acid phosphodiester bond hydrolysis; positive regulation of B cell proliferation; positive regulation of cell cycle G2/M phase transition; positive regulation of DNA replication; positive regulation of isotype switching to IgG isotypes; regulation of mitotic cell cycle phase transition; signal transduction in response to DNA damage
Reference #:  Q96QE3 (UniProtKB)
Alt. Names/Synonyms: ATAD5; ATPase family AAA domain containing 5; ATPase family AAA domain-containing protein 5; ATPase family, AAA domain containing 5; C17orf41; chromosome fragility associated gene 1; Chromosome fragility-associated gene 1 protein; ELG1; enhanced level of genomic instability 1 homolog; FLJ12735; FRAG1
Gene Symbols: ATAD5
Molecular weight: 207,570 Da
Basal Isoelectric point: 9.27  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene