SHIK May be a negative regulator of NF-kappa-B and p53-mediated gene transcription. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. Strongly expressed in heart, brain, placenta, lung, skeletal muscle, kidney, spleen, thymus, prostate, liver, pancreas, testis, ovary, small intestine, colon and peripheral blood leukocytes. 4 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK-Unique family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1p34.3
Cellular Component:  cytosol; nucleoplasm
Molecular Function:  ATP binding; protein binding; protein serine/threonine kinase activity
Biological Process:  glycogen metabolic process; lung alveolus development; lung morphogenesis; multicellular organism growth; negative regulation of apoptotic process; protein phosphorylation; regulation of gene expression; regulation of MAPK cascade; respiratory system process
Reference #:  Q8N2I9 (UniProtKB)
Alt. Names/Synonyms: 2310004N11Rik; MGC4796; RP11-268J15.4; Ser/Thr-like kinase; serine/threonine kinase 40; Serine/threonine-protein kinase 40; SGK495; SHIK; SINK-homologous serine/threonine-protein kinase; STK40; Sugen kinase 495
Gene Symbols: STK40
Molecular weight: 49,001 Da
Basal Isoelectric point: 8.04  Predict pI for various phosphorylation states
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SHIK

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein