SGEF Activates RhoG GTPase by promoting the exchange of GDP by GTP. Required for the formation of membrane ruffles during macropinocytosis. Required for the formation of cup-like structures during trans-endothelial migration of leukocytes. In case of Salmonella enterica infection, activated by SopB, which induces cytoskeleton rearrangements and promotes bacterial entry. Isoform 1 is broadly expressed, with highest levels in liver (at protein level). Certain mRNA species appear to be specifically expressed in prostate and liver. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: GEF; GEF, Rac/Rho
Chromosomal Location of Human Ortholog: 3q25.2
Cellular Component:  cytosol; ruffle
Molecular Function:  Rho guanyl-nucleotide exchange factor activity
Biological Process:  endothelial cell morphogenesis; G protein-coupled receptor signaling pathway; positive regulation of apoptotic process; regulation of Rho protein signal transduction; regulation of small GTPase mediated signal transduction; ruffle assembly
Reference #:  Q96DR7 (UniProtKB)
Alt. Names/Synonyms: ARHGEF26; ARHGQ; CSGEF; DKFZp434D146; HMFN1864; Rho guanine nucleotide exchange factor (GEF) 26; Rho guanine nucleotide exchange factor 26; RP11-23D24.1; SGEF; SH3 domain-containing guanine exchange factor; Src homology 3 domain-containing guanine nucleotide exchange factor; testicular tissue protein Li 171
Gene Symbols: ARHGEF26
Molecular weight: 97,346 Da
Basal Isoelectric point: 9.07  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene