TACC2 Plays a role in the microtubule-dependent coupling of the nucleus and the centrosome. Involved in the processes that regulate centrosome-mediated interkinetic nuclear migration (INM) of neural progenitors. May play a role in organizing centrosomal microtubules. May act as a tumor suppressor protein. May represent a tumor progression marker. Belongs to the TACC family. Strongly expressed in heart, skeletal muscle, brain, prostate, thyroid and trachea. 6 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: Cell cycle regulation
Chromosomal Location of Human Ortholog: 1q37
Cellular Component:  cytoplasm; cytosol; nucleoplasm; plasma membrane
Molecular Function:  nuclear hormone receptor binding; protein domain specific binding
Biological Process:  astral microtubule organization; cell proliferation; cerebral cortex development; interkinetic nuclear migration; microtubule cytoskeleton organization; mitotic spindle organization; neurogenesis; regulation of microtubule-based process
Reference #:  NP_001004415 (RefSeq)
Alt. Names/Synonyms: Tacc2; transforming acidic coiled coil 2; transforming, acidic coiled-coil containing protein 2
Gene Symbols: Tacc2
Molecular weight: 300,230 Da
Basal Isoelectric point: 4.7  Predict pI for various phosphorylation states
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TACC2

Protein Structure Not Found.

Cross-references to other databases:  BioGPS  |  Entrez-Gene  |  GenPept  |  Ensembl Gene