QIK Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily
Chromosomal Location of human Ortholog: 11q23.1
Cellular Component:  cytoplasm; endoplasmic reticulum membrane
Molecular Function:  ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  cellular response to glucose starvation; intracellular signal transduction; protein autophosphorylation; protein phosphorylation; regulation of insulin receptor signaling pathway
Reference #:  Q9H0K1 (UniProtKB)
Alt. Names/Synonyms: DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; salt inducible kinase 2; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2
Gene Symbols: SIK2
Molecular weight: 103,915 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene