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QIK
Phosphorylates 'Ser-794' of IRS1 in insulin-stimulated adipocytes, potentially modulating the efficiency of insulin signal transduction. Inhibits CREB activity by phosphorylating and repressing TORCs, the CREB-specific coactivators. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); QIK subfamily |
| Chromosomal Location of human Ortholog: 11q23.1 |
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Cellular Component:
cytoplasm; endoplasmic reticulum membrane
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Molecular Function:
ATP binding; magnesium ion binding; protein binding; protein serine kinase activity; protein serine/threonine kinase activity
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Biological Process:
cellular response to glucose starvation; intracellular signal transduction; protein autophosphorylation; protein phosphorylation; regulation of insulin receptor signaling pathway
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Reference #:
Q9H0K1
(UniProtKB)
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Alt. Names/Synonyms: DKFZp434K1115; KIAA0781; LOH11CR1I; QIK; Qin-induced kinase; salt inducible kinase 2; salt-inducible kinase 2; Salt-inducible protein kinase 2; salt-inducible serine/threonine kinase 2; Serine/threonine-protein kinase SIK2; Serine/threonine-protein kinase SNF1-like kinase 2; SIK-2; SIK2; SNF1-like kinase 2; SNF1LK2
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Gene Symbols: SIK2
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Molecular weight:
103,915 Da
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Basal Isoelectric point:
5.7
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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