NuaK2 Stress-activated kinase involved in tolerance to glucose starvation. Induces cell-cell detachment by increasing F-actin conversion to G-actin. Expression is induced by CD95 or TNF-alpha, via NF-kappa-B. Protects cells from CD95-mediated apoptosis and is required for the increased motility and invasiveness of CD95-activated tumor cells. Able to phosphorylate 'Ser-464' of LATS1. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; Kinase, protein; NuaK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 1q32.1
Cellular Component: 
Molecular Function:  ATP binding; magnesium ion binding; protein binding; protein serine/threonine kinase activity
Biological Process:  actin cytoskeleton organization; apoptotic process; cellular response to glucose starvation; negative regulation of apoptotic process; protein phosphorylation
Reference #:  Q9H093 (UniProtKB)
Alt. Names/Synonyms: DKFZp434J037; DKFZp686F01113; FLJ90349; NUAK family kinase 2; NUAK family SNF1-like kinase 2; NUAK family, SNF1-like kinase, 2; NUAK2; Omphalocele kinase 2; OMPHK2; SNARK; SNF1/AMP activated protein kinase; SNF1/AMP kinase-related kinase
Gene Symbols: NUAK2
Molecular weight: 69,612 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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NuaK2

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene