MELK Serine/threonine-protein kinase involved in various processes such as cell cycle regulation, self-renewal of stem cells, apoptosis and splicing regulation. Has a broad substrate specificity; phosphorylates BCL2L14, CDC25B, MAP3K5/ASK1 and ZNF622. Acts as an activator of apoptosis by phosphorylating and activating MAP3K5/ASK1. Acts as a regulator of cell cycle, notably by mediating phosphorylation of CDC25B, promoting localization of CDC25B to the centrosome and the spindle poles during mitosis. Plays a key role in cell proliferation and carcinogenesis. Required for proliferation of embryonic and postnatal multipotent neural progenitors. Phosphorylates and inhibits BCL2L14, possibly leading to affect mammary carcinogenesis by mediating inhibition of the pro-apoptotic function of BCL2L14. Also involved in the inhibition of spliceosome assembly during mitosis by phosphorylating ZNF622, thereby contributing to its redirection to the nucleus. May also play a role in primitive hematopoiesis. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Expressed in placenta, kidney, thymus, testis, ovary and intestine. 8 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.10.2; EC 2.7.11.1; Kinase, protein; MELK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor); Protein kinase, tyrosine (non-receptor); RNA splicing
Chromosomal Location of human Ortholog: 9p13.2
Cellular Component:  cell cortex; plasma membrane
Molecular Function:  ATP binding; calcium ion binding; lipid binding; non-membrane spanning protein tyrosine kinase activity; protein binding; protein serine/threonine kinase activity
Biological Process:  apoptotic process; cell proliferation; G2/M transition of mitotic cell cycle; hemopoiesis; intrinsic apoptotic signaling pathway in response to oxidative stress; neural precursor cell proliferation; peptidyl-tyrosine phosphorylation; positive regulation of apoptotic process; protein autophosphorylation
Reference #:  Q14680 (UniProtKB)
Alt. Names/Synonyms: hMELK; hPK38; KIAA0175; Maternal embryonic leucine zipper kinase; MELK; pEg3 kinase; Protein kinase Eg3; Protein kinase PK38; Tyrosine-protein kinase MELK
Gene Symbols: MELK
Molecular weight: 74,642 Da
Basal Isoelectric point: 8.92  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MELK

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Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene