MARK1 Serine/threonine-protein kinase. Involved in cell polarity and microtubule dynamics regulation. Phosphorylates DCX, MAP2 and MAP4. Phosphorylates the microtubule-associated protein MAPT/TAU. Involved in cell polarity by phosphorylating the microtubule-associated proteins MAP2, MAP4 and MAPT/TAU at KXGS motifs, causing detachment from microtubules, and their disassembly. Involved in the regulation of neuronal migration through its dual activities in regulating cellular polarity and microtubule dynamics, possibly by phosphorylating and regulating DCX. Also acts as a positive regulator of the Wnt signaling pathway, probably by mediating phosphorylation of dishevelled proteins (DVL1, DVL2 and/or DVL3). Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Highly expressed in heart, skeletal muscle, brain, fetal brain and fetal kidney. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; MARK subfamily; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of human Ortholog: 1q41
Cellular Component:  cytoplasm; cytoskeleton; dendrite; microtubule cytoskeleton; plasma membrane
Molecular Function:  ATP binding; magnesium ion binding; phosphatidic acid binding; phosphatidylinositol-4,5-bisphosphate binding; phosphatidylserine binding; protein binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  cytoskeleton organization; establishment of cell polarity; establishment of mitochondrion localization; intracellular signal transduction; microtubule cytoskeleton organization; neuron migration; peptidyl-serine phosphorylation; protein phosphorylation; regulation of dendrite development; regulation of neuron projection development; Wnt signaling pathway
Reference #:  Q9P0L2 (UniProtKB)
Alt. Names/Synonyms: KIAA1477; MAP/microtubule affinity-regulating kinase 1; MARK; MARK1; MGC126512; MGC126513; microtubule affinity regulating kinase 1; Par-1c; PAR1 homolog c; Par1c; Serine/threonine-protein kinase MARK1
Gene Symbols: MARK1
Molecular weight: 89,003 Da
Basal Isoelectric point: 9.42  Predict pI for various phosphorylation states
CST Pathways:  Microtubule Dynamics
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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MARK1

Protein Structure Not Found.


Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  KinBase  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene