GPR97 Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development. Seems to signal through G-alpha(q)-proteins. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed in cultured primary dermal lymphatic endothelial cells. Note: This description may include information from UniProtKB.
Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR
Chromosomal Location of human Ortholog: 16q21
Cellular Component:  membrane; plasma membrane; specific granule membrane
Molecular Function:  G protein-coupled receptor activity; protein binding
Biological Process:  adenylate cyclase-activating G protein-coupled receptor signaling pathway; B cell differentiation; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of CREB transcription factor activity; negative regulation of NIK/NF-kappaB signaling; regulation of cell migration
Reference #:  Q86Y34 (UniProtKB)
Alt. Names/Synonyms: ADGRG3; Adhesion G protein-coupled receptor G3; AGRG3; EGF-TM7-like; G protein-coupled receptor 97; G-protein coupled receptor 97; G-protein coupled receptor PGR26; GPR97; PB99; PGR26; Probable G-protein coupled receptor 97
Gene Symbols: ADGRG3
Molecular weight: 60,861 Da
Basal Isoelectric point: 9.01  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein