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GPR97
Orphan receptor that regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Regulates B-cell development. Seems to signal through G-alpha(q)-proteins. Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily. Expressed in cultured primary dermal lymphatic endothelial cells. Note: This description may include information from UniProtKB.
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| Protein type: GPCR, family 2; Membrane protein, integral; Membrane protein, multi-pass; Receptor, GPCR |
| Chromosomal Location of human Ortholog: 16q21 |
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Cellular Component:
membrane; plasma membrane; specific granule membrane
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Molecular Function:
G protein-coupled receptor activity; protein binding
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Biological Process:
adenylate cyclase-activating G protein-coupled receptor signaling pathway; B cell differentiation; cell surface receptor signaling pathway; G protein-coupled receptor signaling pathway; negative regulation of CREB transcription factor activity; negative regulation of NIK/NF-kappaB signaling; regulation of cell migration
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Reference #:
Q86Y34
(UniProtKB)
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Alt. Names/Synonyms: ADGRG3; Adhesion G protein-coupled receptor G3; AGRG3; EGF-TM7-like; G protein-coupled receptor 97; G-protein coupled receptor 97; G-protein coupled receptor PGR26; GPR97; PB99; PGR26; Probable G-protein coupled receptor 97
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Gene Symbols: ADGRG3
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Molecular weight:
60,861 Da
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Basal Isoelectric point:
9.01
Predict pI for various phosphorylation states
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