BRSK1 iso2 Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B, CDC25C, MAPT/TAU, RIMS1, TUBG1, TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. In neurons, localizes to synaptic vesicles and plays a role in neurotransmitter release, possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131', leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response, probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1, and inhibition of CDC25B and CDC25C. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. Widely expressed, with highest levels in brain and testis. Protein levels remain constant throughout the cell cycle. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: BRSK subfamily; CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component:  cell junction; centrosome; cytoplasm; distal axon; nucleoplasm; nucleus; presynaptic active zone; synaptic vesicle
Molecular Function:  ATP binding; gamma-tubulin binding; magnesium ion binding; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  associative learning; axonogenesis; cellular response to DNA damage stimulus; centrosome duplication; establishment of cell polarity; microtubule cytoskeleton organization involved in establishment of planar polarity; mitotic G2 DNA damage checkpoint; neuron differentiation; neurotransmitter secretion; protein phosphorylation; regulation of axonogenesis; regulation of neuron projection development; regulation of synaptic plasticity; regulation of synaptic vesicle clustering; response to UV; synaptic vesicle cycle
Reference #:  Q8TDC3-2 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; Brain-selective kinase 1; Brain-specific serine/threonine-protein kinase 1; BRSK1; BRSK1 iso2; FLJ43009; hSAD1; KIAA1811; protein kinase SAD1A; SAD1; SAD1 homolog; SAD1 kinase; SADB; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B; Synapses of Amphids Defective homolog 1
Gene Symbols: BRSK1
Molecular weight: 86,753 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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BRSK1 iso2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene