BRSK1 iso2 a serine/threonine protein kinase of the CAMK group. Closely related to AMPK. Activated by the kinase LKB1. Acts as checkpoint kinase upon DNA damage induced by UV or methyl methane sulfonate. Phosphorylates WEE1 and CDC25B in vitro and CDC25C in vitro and in vivo. Translocates from the cytoplasm to the nucleus in response to UV- or MMS-induced DNA damage. BRSK1 and BRSK2 are required for neuronal polarization. Widely expressed with highest levels in the brain and testis. Two alternatively spliced isoforms have been described. Note: This description may include information from UniProtKB.
Protein type: BRSK subfamily; CAMK group; CAMKL family; EC 2.7.11.1; EC 2.7.11.26; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of Human Ortholog: 19q13.42
Cellular Component:  cell junction; centrosome; cytoplasm; distal axon; nucleoplasm; nucleus; presynaptic active zone; synaptic vesicle
Molecular Function:  ATP binding; gamma-tubulin binding; magnesium ion binding; protein kinase binding; protein serine/threonine kinase activity; tau protein binding; tau-protein kinase activity
Biological Process:  associative learning; axonogenesis; cellular response to DNA damage stimulus; centrosome duplication; establishment of cell polarity; microtubule cytoskeleton organization involved in establishment of planar polarity; mitotic G2 DNA damage checkpoint; neuron differentiation; neurotransmitter secretion; protein phosphorylation; regulation of axonogenesis; regulation of neuron projection development; regulation of synaptic plasticity; regulation of synaptic vesicle clustering; response to UV; synaptic vesicle cycle
Reference #:  Q8TDC3-2 (UniProtKB)
Alt. Names/Synonyms: BR serine/threonine kinase 1; BR serine/threonine-protein kinase 1; BRSK1; FLJ43009; KIAA1811; protein kinase SAD1A; SAD1; SAD1 kinase; Serine/threonine-protein kinase BRSK1; Serine/threonine-protein kinase SAD-B
Gene Symbols: BRSK1
Molecular weight: 86,753 Da
Basal Isoelectric point: 9.08  Predict pI for various phosphorylation states
Protein-Specific Antibodies or siRNAs from Cell Signaling Technology® Total Proteins
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BRSK1 iso2

Protein Structure Not Found.


Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  KinBase  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene