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VMP1
Stress-induced protein that, when overexpressed, promotes formation of intracellular vacuoles followed by cell death. May be involved in the cytoplasmic vacuolization of acinar cells during the early stage of acute pancreatitis. Plays a role in the initial stages of the autophagic process through its interaction with BECN1. Involved in cell-cell adhesion. Plays an essential role in formation of cell junctions. Required for autophagosome formation. Belongs to the VMP1 family. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: Endoplasmic reticulum; Membrane protein, integral; Membrane protein, multi-pass |
| Chromosomal Location of human Ortholog: 17q23.1 |
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Cellular Component:
autophagosome membrane; endomembrane system; endoplasmic reticulum; endoplasmic reticulum membrane; endoplasmic reticulum-Golgi intermediate compartment membrane; membrane; nucleolus; phagophore assembly site; plasma membrane
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Molecular Function:
phospholipid scramblase activity; protein binding
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Biological Process:
autophagosome assembly; autophagosome membrane docking; autophagy; cell junction assembly; cell-cell adhesion; embryo implantation; Golgi organization; lipoprotein transport; mitochondrion-endoplasmic reticulum membrane tethering; organelle localization by membrane tethering; plasma membrane phospholipid scrambling; positive regulation of ATPase-coupled calcium transmembrane transporter activity
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Reference #:
Q96GC9
(UniProtKB)
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Alt. Names/Synonyms: DKFZp566I133; ectopic P-granules autophagy protein 3 homolog; EPG3; TANGO5; TDC1; TMEM49; TMM49; Transmembrane protein 49; transport and golgi organization 5 homolog; Vacuole membrane protein 1; VMP1
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Gene Symbols: VMP1
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Molecular weight:
46,238 Da
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Basal Isoelectric point:
6.47
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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