TMBIM1 Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. Belongs to the BI1 family. LFG subfamily. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral; Membrane protein, multi-pass
Chromosomal Location of Human Ortholog: 2q35
Cellular Component:  endosome membrane; Golgi apparatus; integral component of membrane; intracellular membrane-bounded organelle; lysosomal membrane; plasma membrane; specific granule membrane
Molecular Function:  death receptor binding
Biological Process:  negative regulation of catalytic activity; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of Fas signaling pathway; negative regulation of protein localization to plasma membrane; neutrophil degranulation; positive regulation of blood vessel remodeling
Reference #:  Q969X1 (UniProtKB)
Alt. Names/Synonyms: LFG3; MST100; MSTP100; PP1201; Protein lifeguard 3; Protein RECS1 homolog; RECS1; TMBI1; TMBIM1; transmembrane BAX inhibitor motif containing 1; Transmembrane BAX inhibitor motif-containing protein 1
Gene Symbols: TMBIM1
Molecular weight: 34,607 Da
Basal Isoelectric point: 7.6  Predict pI for various phosphorylation states
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Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene