TMBIM1
Negatively regulates aortic matrix metalloproteinase-9 (MMP9) production and may play a protective role in vascular remodeling. Belongs to the BI1 family. LFG subfamily. Note: This description may include information from UniProtKB.
|
Protein type: Membrane protein, integral; Membrane protein, multi-pass |
Chromosomal Location of human Ortholog: 2q35 |
Cellular Component:
endoplasmic reticulum; endosome membrane; Golgi apparatus; intracellular membrane-bounded organelle; lysosomal membrane; membrane; plasma membrane; specific granule membrane
|
Molecular Function:
death receptor binding; protein binding
|
Biological Process:
negative regulation of apoptotic signaling pathway; negative regulation of catalytic activity; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; negative regulation of Fas signaling pathway; negative regulation of protein localization to plasma membrane; positive regulation of blood vessel remodeling
|
Reference #:
Q969X1
(UniProtKB)
|
Alt. Names/Synonyms: LFG3; MST100; MSTP100; PP1201; Protein lifeguard 3; Protein RECS1 homolog; RECS1; TMBI1; TMBIM1; transmembrane BAX inhibitor motif containing 1; Transmembrane BAX inhibitor motif-containing protein 1
|
Gene Symbols: TMBIM1
|
Molecular weight:
34,607 Da
|
Basal Isoelectric point:
7.6
Predict pI for various phosphorylation states
|