CAMK2G Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in skeletal muscle. 11 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: CAMK group; CAMK2 family; EC; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor)
Chromosomal Location of rat Ortholog: 15p16
Cellular Component:  calcium- and calmodulin-dependent protein kinase complex; cytoplasm; cytosol; neuron projection; nucleoplasm; organelle; postsynaptic density; sarcoplasmic reticulum membrane
Molecular Function:  ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein homodimerization activity; protein serine kinase activity; protein serine/threonine kinase activity
Biological Process:  calcium ion transport; cell differentiation; G1/S transition of mitotic cell cycle; nervous system development; protein autophosphorylation; protein phosphorylation; regulation of long-term neuronal synaptic plasticity; regulation of neuron projection development; regulation of protein localization to plasma membrane; regulation of relaxation of cardiac muscle; response to hypoxia; response to oxidative stress
Reference #:  P11730 (UniProtKB)
Alt. Names/Synonyms: calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase type II gamma chain; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; caM-kinase II gamma chain; CaMK-II subunit gamma; Camk2g; KCC2G
Gene Symbols: Camk2g
Molecular weight: 59,038 Da
Basal Isoelectric point: 7.63  Predict pI for various phosphorylation states
CST Pathways:  B Cell Receptor Signaling  |  ErbB/HER Signaling  |  GPCR Signaling to MAPKs  |  Microtubule Dynamics  |  Mitochondrial Control of Apoptosis  |  Phospholipase Signaling
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  Reactome  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene