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CAMK2G
Calcium/calmodulin-dependent protein kinase that functions autonomously after Ca(2+)/calmodulin-binding and autophosphorylation, and is involved in sarcoplasmic reticulum Ca(2+) transport in skeletal muscle and may function in dendritic spine and synapse formation and neuronal plasticity. In slow-twitch muscles, is involved in regulation of sarcoplasmic reticulum (SR) Ca(2+) transport and in fast-twitch muscle participates in the control of Ca(2+) release from the SR through phosphorylation of the ryanodine receptor-coupling factor triadin. In neurons, may participate in the promotion of dendritic spine and synapse formation and maintenance of synaptic plasticity which enables long-term potentiation (LTP) and hippocampus-dependent learning. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Expressed in skeletal muscle. 11 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; CAMK2 family; EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 10q22.2 |
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Cellular Component:
calcium- and calmodulin-dependent protein kinase complex; cytoplasm; cytosol; endocytic vesicle membrane; neuron projection; nucleoplasm; sarcoplasmic reticulum membrane
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Molecular Function:
ATP binding; calcium-dependent protein serine/threonine phosphatase activity; calmodulin binding; calmodulin-dependent protein kinase activity; identical protein binding; protein binding; protein homodimerization activity; protein serine kinase activity
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Biological Process:
cell differentiation; insulin secretion; nervous system development; protein phosphorylation; regulation of calcium ion transport; regulation of neuron projection development; regulation of skeletal muscle adaptation
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Disease: Intellectual Developmental Disorder 59
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Reference #:
Q13555
(UniProtKB)
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Alt. Names/Synonyms: calcium/calmodulin dependent protein kinase II gamma; calcium/calmodulin-dependent protein kinase (CaM kinase) II gamma; calcium/calmodulin-dependent protein kinase II gamma; Calcium/calmodulin-dependent protein kinase type II subunit gamma; CaM kinase II subunit gamma; CAMK; CAMK-II; CaMK-II subunit gamma; CAMK2G; CAMKG; CaMKII; FLJ16043; KCC2G; MGC26678; MRD59
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Gene Symbols: CAMK2G
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Molecular weight:
62,607 Da
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Basal Isoelectric point:
7.9
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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GPCR Signaling to MAPKs
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Microtubule Dynamics
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Mitochondrial Control of Apoptosis
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Phospholipase Signaling
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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