POFUT2 Catalyzes the reaction that attaches fucose through an O-glycosidic linkage to a conserved serine or threonine residue in the consensus sequence C1-X(2,3)-S/T-C2-X(2)-G of thrombospondin type 1 repeats where C1 and C2 are the first and second cysteines, respectively. O-fucosylates members of several protein families including the ADAMTS family, the thrombosporin (TSP) and spondin families. The O-fucosylation of TSRs is also required for restricting epithelial to mesenchymal transition (EMT), maintaining the correct patterning of mesoderm and localization of the definite endoderm. Required for the proper secretion of ADAMTS family members such as ADAMSL1 and ADAMST13. Belongs to the glycosyltransferase 68 family. Isoform A is expressed in fetal liver and peripheral blood lymphocytes. Isoform B is expressed in spleen, lung, testis, bone marrow, thymus, pancreas, prostate, fetal brain, fetal liver and fetal kidney. Isoform C is expressed in brain, heart, spleen, liver, lung, stomach, testis, placenta, skin, thymus, pancreas, mammary gland, prostate, fetal brain, fetal liver and fetal heart. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; Transferase
Chromosomal Location of Human Ortholog: 21q22.3
Cellular Component:  endoplasmic reticulum membrane; Golgi apparatus
Molecular Function:  peptide-O-fucosyltransferase activity
Biological Process:  fucose metabolic process; mesoderm formation; protein O-linked fucosylation; regulation of epithelial to mesenchymal transition; regulation of gene expression; regulation of secretion
Reference #:  Q9Y2G5 (UniProtKB)
Alt. Names/Synonyms: C21orf80; FUT13; GDP-fucose protein O-fucosyltransferase 2; KIAA0958; O-FucT-2; OFUT2; Peptide-O-fucosyltransferase 2; POFUT2; protein O-fucosyltransferase 2
Gene Symbols: POFUT2
Molecular weight: 49,976 Da
Basal Isoelectric point: 6.15  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  InnateDB  |  Ensembl Protein