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CAMK1D
Calcium/calmodulin-dependent protein kinase that operates in the calcium-triggered CaMKK-CaMK1 signaling cascade and, upon calcium influx, activates CREB-dependent gene transcription, regulates calcium-mediated granulocyte function and respiratory burst and promotes basal dendritic growth of hippocampal neurons. In neutrophil cells, required for cytokine-induced proliferative responses and activation of the respiratory burst. Activates the transcription factor CREB1 in hippocampal neuron nuclei. May play a role in apoptosis of erythroleukemia cells. In vitro, phosphorylates transcription factor CREM isoform Beta. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. Widely expressed. Highly and mostly expressed in polymorphonuclear leukocytes (neutrophilic and eosinophilic granulocytes) while little or no expression is observed in monocytes and lymphocytes. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: CAMK group; CAMK1 family; EC 2.7.11.17; Kinase, protein; Protein kinase, CAMK; Protein kinase, Ser/Thr (non-receptor) |
| Chromosomal Location of human Ortholog: 10p13 |
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Cellular Component:
cytoplasm; intracellular anatomical structure; nucleus
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Molecular Function:
ATP binding; calmodulin binding; calmodulin-dependent protein kinase activity; protein binding; protein serine kinase activity
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Biological Process:
inflammatory response; negative regulation of apoptotic process; nervous system development; peptidyl-serine phosphorylation; positive regulation of apoptotic process; positive regulation of CREB transcription factor activity; positive regulation of neuron projection development; positive regulation of neutrophil chemotaxis; positive regulation of phagocytosis; positive regulation of respiratory burst; regulation of dendrite development; regulation of granulocyte chemotaxis
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Reference #:
Q8IU85
(UniProtKB)
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Alt. Names/Synonyms: calcium/calmodulin dependent protein kinase ID; calcium/calmodulin-dependent protein kinase ID; Calcium/calmodulin-dependent protein kinase type 1D; CaM kinase I delta; CaM kinase ID; CaM-K1; CaM-KI delta; CAMK1D; CAMK1D/ANAPC5 fusion; CaMKI delta; CaMKI-like protein kinase; CaMKID; CKLiK; KCC1D
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Gene Symbols: CAMK1D
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Molecular weight:
42,914 Da
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Basal Isoelectric point:
6.77
Predict pI for various phosphorylation states
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CST Pathways:
B Cell Receptor Signaling
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ErbB/HER Signaling
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Microtubule Dynamics
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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