|
PIGZ
Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to some trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is facultative and only scarcely detected, suggesting that it only exists in some tissues. Belongs to the glycosyltransferase 22 family. PIGZ subfamily. Widely expressed at low level, with highest level in brain and colon. Note: This description may include information from UniProtKB.
|
| Protein type: EC 2.4.1.-; Endoplasmic reticulum; Glycan Metabolism - glycosylphosphatidylinositol (GPI)-anchor biosynthesis; Membrane protein, integral; Membrane protein, multi-pass; Transferase |
| Chromosomal Location of human Ortholog: 3q29 |
|
Cellular Component:
endoplasmic reticulum; endoplasmic reticulum membrane
|
|
Molecular Function:
alpha-1,2-mannosyltransferase activity; mannosyltransferase activity
|
|
Biological Process:
GPI anchor biosynthetic process; preassembly of GPI anchor in ER membrane
|
|
Reference #:
Q86VD9
(UniProtKB)
|
|
Alt. Names/Synonyms: dol-P-Man dependent GPI mannosyltransferase; FLJ12768; GPI mannosyltransferase 4; GPI mannosyltransferase IV; GPI-MT-IV; hSMP3; MGC52163; phosphatidylinositol glycan anchor biosynthesis class Z; phosphatidylinositol glycan anchor biosynthesis, class Z; phosphatidylinositol glycan, class Z; Phosphatidylinositol-glycan biosynthesis class Z protein; PIG-Z; PIGZ; SMP3; SMP3 homolog; SMP3 mannosyltransferase
|
|
Gene Symbols: PIGZ
|
|
Molecular weight:
63,471 Da
|
|
Basal Isoelectric point:
8.66
Predict pI for various phosphorylation states
|
