PH4 Catalyzes the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates HIF1A at 'Pro-402' and 'Pro-564'. May function as a cellular oxygen sensor and, under normoxic conditions, may target HIF through the hydroxylation for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Widely expressed with highest levels in adult pancreas, heart, skeletal muscle, brain, placenta, kidney and adrenal gland. Expressed at lower levels in epiphyseal cartilage and in fibroblasts. 3 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC 1.14.11.-; Membrane protein, integral; Oxidoreductase
Chromosomal Location of Human Ortholog: 9|9 F2
Cellular Component:  endoplasmic reticulum; integral component of membrane; membrane
Molecular Function:  calcium ion binding; dioxygenase activity; iron ion binding; L-ascorbic acid binding; metal ion binding; oxidoreductase activity; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen; oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, 2-oxoglutarate as one donor, and incorporation of one atom each of oxygen into both donors
Biological Process:  oxidation-reduction process; peptidyl-proline hydroxylation to 4-hydroxy-L-proline; regulation of erythrocyte differentiation
Reference #:  Q8BG58 (UniProtKB)
Alt. Names/Synonyms: 4933406E20Rik; AI853847; BB128974; HIF-PH4; HIF-prolyl hydroxylase 4; HPH-4; Hypoxia-inducible factor prolyl hydroxylase 4; MGC130597; P4H-TM; P4htm; Ph-4; Ph4; prolyl 4-hydroxylase, transmembrane (endoplasmic reticulum); Transmembrane prolyl 4-hydroxylase
Gene Symbols: P4htm
Molecular weight: 57,049 Da
Basal Isoelectric point: 5.7  Predict pI for various phosphorylation states
Select Structure to View Below

PH4

Protein Structure Not Found.

Cross-references to other databases:  STRING  |  BioGPS  |  Pfam  |  ENZYME  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  Ensembl Gene