NFAM1 May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking. Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue. Note: This description may include information from UniProtKB.
Protein type: Membrane protein, integral
Chromosomal Location of Human Ortholog: 22q13.2
Cellular Component:  azurophil granule membrane; integral component of membrane; plasma membrane
Molecular Function:  transmembrane signaling receptor activity
Biological Process:  B cell differentiation; cell surface receptor signaling pathway; inflammatory response; intracellular signal transduction; neutrophil degranulation; positive regulation of B cell receptor signaling pathway; positive regulation of cytokine production; positive regulation of DNA-binding transcription factor activity; regulation of B cell differentiation; signal transduction
Reference #:  Q8NET5 (UniProtKB)
Alt. Names/Synonyms: bK126B4.4; calcinerin/NFAT-activating ITAM-containing protein; Calcineurin/NFAT-activating ITAM-containing protein; CNAIP; FLJ40652; NFAM1; NFAT activating protein with ITAM motif 1; NFAT activation molecule 1; NFAT-activating protein with ITAM motif 1
Gene Symbols: NFAM1
Molecular weight: 29,686 Da
Basal Isoelectric point: 9.04  Predict pI for various phosphorylation states
Select Structure to View Below


Protein Structure Not Found.

Cross-references to other databases:  STRING  |  cBioPortal  |  Wikipedia  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  Phospho.ELM  |  NetworKIN  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene