DUSP3 Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
Protein type: EC; EC; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity
Chromosomal Location of human Ortholog: 17q21.31
Cellular Component:  cytoplasm; cytosol; immunological synapse; nucleoplasm; nucleus
Molecular Function:  cytoskeletal protein binding; MAP kinase phosphatase activity; myosin phosphatase activity; phosphatase activity; protein binding; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; receptor tyrosine kinase binding
Biological Process:  cellular response to epidermal growth factor stimulus; dephosphorylation; negative regulation of cell migration; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of MAPK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of focal adhesion disassembly; positive regulation of mitotic cell cycle; regulation of focal adhesion assembly
Reference #:  P51452 (UniProtKB)
Alt. Names/Synonyms: dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3; DUSP3; serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
Gene Symbols: DUSP3
Molecular weight: 20,478 Da
Basal Isoelectric point: 7.66  Predict pI for various phosphorylation states
Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology® Total Proteins
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Protein Structure Not Found.

Cross-references to other databases:  AlphaFold  |  STRING  |  cBioPortal  |  Wikipedia  |  Reactome  |  neXtProt  |  Protein Atlas  |  BioGPS  |  Pfam  |  RCSB PDB  |  ENZYME  |  Phospho3D  |  Phospho.ELM  |  NetworKIN  |  GeneCards  |  UniProtKB  |  Entrez-Gene  |  GenPept  |  Ensembl Gene  |  Ensembl Protein