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DUSP3
Shows activity both for tyrosine-protein phosphate and serine-protein phosphate, but displays a strong preference toward phosphotyrosines. Specifically dephosphorylates and inactivates ERK1 and ERK2. Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. 2 alternatively spliced human isoforms have been reported. Note: This description may include information from UniProtKB.
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| Protein type: EC 3.1.3.16; EC 3.1.3.48; Motility/polarity/chemotaxis; Protein phosphatase, dual-specificity |
| Chromosomal Location of Human Ortholog: 17q21.31 |
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Cellular Component:
cytosol; immunological synapse; nucleoplasm; nucleus
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Molecular Function:
cytoskeletal protein binding; MAP kinase phosphatase activity; phosphatase activity; protein kinase binding; protein tyrosine kinase binding; protein tyrosine phosphatase activity; protein tyrosine/serine/threonine phosphatase activity; receptor tyrosine kinase binding
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Biological Process:
cellular response to epidermal growth factor stimulus; dephosphorylation; inactivation of MAPK activity; negative regulation of cell migration; negative regulation of chemotaxis; negative regulation of epidermal growth factor receptor signaling pathway; negative regulation of ERK1 and ERK2 cascade; negative regulation of JNK cascade; negative regulation of MAPK cascade; negative regulation of T cell activation; negative regulation of T cell receptor signaling pathway; peptidyl-tyrosine dephosphorylation; peptidyl-tyrosine dephosphorylation involved in inactivation of protein kinase activity; positive regulation of focal adhesion disassembly; positive regulation of mitotic cell cycle; regulation of focal adhesion assembly
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Reference #:
P51452
(UniProtKB)
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Alt. Names/Synonyms: dual specificity phosphatase 3; Dual specificity protein phosphatase 3; Dual specificity protein phosphatase VHR; DUS3; DUSP3; serine/threonine specific protein phosphatase; Vaccinia H1-related phosphatase; vaccinia virus phosphatase VH1-related; VHR
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Gene Symbols: DUSP3
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Molecular weight:
20,478 Da
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Basal Isoelectric point:
7.66
Predict pI for various phosphorylation states
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Protein-Specific Antibodies, siRNAs or Recombinant Proteins from Cell Signaling Technology®
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