IVNS1ABP
Involved in many cell functions, including pre-mRNA splicing, the aryl hydrocarbon receptor (AHR) pathway, F-actin organization and protein ubiquitination. Plays a role in the dynamic organization of the actin skeleton as a stabilizer of actin filaments by association with F-actin through Kelch repeats. Protects cells from cell death induced by actin destabilization. Functions as modifier of the AHR/Aryl hydrocarbon receptor pathway increasing the concentration of AHR available to activate transcription. In addition, functions as a negative regulator of BCR(KLHL20) E3 ubiquitin ligase complex to prevent ubiquitin-mediated proteolysis of PML and DAPK1, two tumor suppressors. Inhibits pre-mRNA splicing (in vitro). (Microbial infection) Involved in the alternative splicing of influenza A virus M1 mRNA through interaction with HNRNPK, thereby facilitating the generation of viral M2 protein. Note: This description may include information from UniProtKB.
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Chromosomal Location of human Ortholog: 1q25.3 |
Cellular Component:
cytoskeleton; cytosol; nucleoplasm; spliceosomal complex; transcription regulator complex
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Molecular Function:
protein binding
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Biological Process:
intrinsic apoptotic signaling pathway; negative regulation of intrinsic apoptotic signaling pathway; negative regulation of protein ubiquitination; response to virus; RNA splicing; transcription by RNA polymerase III
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Disease: Immunodeficiency 70
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Reference #:
Q9Y6Y0
(UniProtKB)
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Alt. Names/Synonyms: ARA3; aryl hydrocarbon receptor-associated 3; Aryl hydrocarbon receptor-associated protein 3; DKFZp686K06216; FLARA3; FLJ10069; FLJ10411; FLJ10962; FLJ35593; FLJ36593; HSPC068; IMD70; influenza virus NS1A binding protein; Influenza virus NS1A-binding protein; IVNS1ABP; kelch-like family member 39; Kelch-like protein 39; KIAA0850; KLHL39; NCX downstream gene 1; ND1; NS-1; NS1; NS1-binding protein; NS1-BP; NS1BP
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Gene Symbols: IVNS1ABP
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Molecular weight:
71,729 Da
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Basal Isoelectric point:
5.33
Predict pI for various phosphorylation states
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